Scientific Lecture XVI

Topic: Three short stories on polycystic kidney disease
"Three hit" hypothesis, centrosomes and planar cell polarity
Speaker: Dr. Jing Zhou

Associate Professor, Brigham & Women¡¯s Hospital
Department of Genetics, Harvard Medical School

Time: 6:30-8:00PM, July 16th, Friday, 2010
Location: T-MEC, Room L-007, 260 Longwood Avenue.
Pizza and beverages will be served. Everyone is welcome!

The primary emphasis of Dr. Zhou¡¯s research is on the molecular basi
s of
inherited renal diseases, particularly autosomal dominant polycystic kidn
ey
disease (ADPKD), and the function of polycystins. A particular strength o
f
the lab is that they are using an unusually wide range of approaches.
Techniques that are employed in the laboratory include: molecular cloning
,
immunocytochemistry, gene transfection, small RNA interference, promoter

analysis by reporter gene assays, microarray analysis, immunoprecipitatio
n,
subcellular fractionation, in situ hybridization, Southern, Northern and

western analysis, patch clamping, various transgenic techniques including

conditional tageting technology and Ca2+ imaging.